Hair loss consultation at Dr Sin Yong's clinic, Orchard Road, Singapore
Autologous Micrografting · Orchard Road, Singapore

Regenera Activa in Singapore

Medically reviewed by Dr Sin Yong · Last reviewed · 16 min read · Doctor-performed, never delegated · Jump to questions

Dr Sin Yong · MBBS (NUS) · MRCS (Edin) · MSc Aesthetic Medicine with Distinction (Queen Mary, London) · MSc Practical Dermatology (Cardiff) · International KOL

An autologous micrografting hair loss treatment in Singapore, used for both male and female pattern loss. Tissue is taken from the patient's own DHT-protected scalp, processed into a micrograft suspension, and returned to the thinning area — all within a single session.

Doctor-ledEvery assessment by Dr Sin Yong
MBBS · MRCS · MSc ×2NUS · Edinburgh · London · Cardiff
Orchard RoadBy appointment

Regenera Activa is an autologous micrografting treatment for male and female pattern hair loss in Singapore. Small samples of the patient's own scalp from the hormone-resistant zone are processed into a micrograft suspension and returned to thinning areas at the same visit. Staging comes first, because it works on miniaturising follicles, not ones already lost.

Key takeaways
  • Regenera Activa is an autologous micrografting treatment for male and female pattern hair loss, using the patient's own scalp tissue.
  • It acts on miniaturising follicles still present; follicles already lost cannot respond, so staging comes first.
  • It is not a hair transplant, and it is not accurately a stem cell treatment, because the suspension contains progenitor cells.
  • Suitability depends on the pattern, stage and cause of hair loss; other causes are excluded first.
  • Dr Sin Yong, an aesthetic physician, assesses, stages and performs the procedure personally.

Staging Comes First

Before any discussion of treatment, the pattern and stage of hair loss need establishing. This is not administrative. Androgenetic alopecia is progressive, and follicles pass through miniaturisation before they are lost altogether. A follicle that is miniaturising can still respond. One that has gone cannot.

Staging tells you which of those you are dealing with, and therefore what any hair loss treatment can realistically be expected to do. This applies equally to male hair loss treatment and to female hair loss treatment in Singapore. Two standard classifications are used, one for each pattern.

“Staging is not paperwork. It tells you how many follicles are still there to work with, and that decides what is realistic.”

Dr Sin YongOn assessing hair loss

The Norwood Scale — Male Pattern Hair Loss

The Norwood scale is the standard classification for male hair loss, and the reference point for any male hair loss treatment in Singapore. It runs from Type I to Type VII and describes a characteristic progression: recession at the temples, then loss at the vertex, then the merging of the two.

Norwood classification — male pattern hair loss
StageWhat it describes
Type INo recession, or minimal recession at the hairline that falls within normal adult variation.
Type IISlight symmetrical recession at the temples. The frontal hairline begins to take on a triangular shape.
Type IIIThe first stage regarded as clinically significant balding. Deep temporal recession, symmetrical, forming an M, U or V shape.
Type III vertexTemporal recession as in Type III, with loss additionally at the vertex — the crown.
Type IVMore pronounced frontal and temporal recession, with a larger area of vertex loss. A bridge of hair separates the two regions.
Type VThe bridge between the frontal and vertex areas narrows and begins to break down.
Type VIThe bridge is lost. The frontal and vertex areas of loss have merged into a single region.
Type VIIOnly a band of hair remains around the sides and back of the scalp.
Male patient consultation for pattern hair loss assessment, Dr Sin Yong, Orchard Road, Singapore
Male pattern loss is staged on the Norwood scale, which describes recession at the temples and loss at the vertex.

Type III is generally regarded as the first stage of clinically significant balding. The earlier the stage, the more miniaturising follicles remain, and the more scope any treatment has to work with.

The Ludwig Scale — Female Pattern Hair Loss

Female hair loss treatment in Singapore begins from a different pattern, which is why applying the Norwood scale to women misses what is actually happening. Where male loss recedes, female loss diffuses — and the frontal hairline is typically preserved throughout.

Ludwig classification — female pattern hair loss
GradeWhat it describes
Grade IPerceptible thinning over the crown, with the frontal hairline preserved. Often first noticed as a widening central parting rather than as recession.
Grade IIPronounced widening of the central parting, with a visible decrease in density across the crown.
Grade IIIDiffuse thinning across the crown, with the scalp readily visible through the remaining hair. The frontal hairline typically remains.
Central parting of the scalp — the presentation assessed in female pattern hair loss on the Ludwig scale
In female pattern loss the frontal hairline is typically preserved; the central parting is where change appears first.

The usual first sign is a widening central parting rather than a receding hairline. Women also present more often with non-androgenetic causes — thyroid dysfunction, iron deficiency, telogen effluvium after childbirth or illness — which behave differently and are excluded before pattern loss is assumed.

How Regenera Activa Works

The procedure rests on a straightforward observation: not all scalp follicles are equally affected by DHT. Those at the back and sides — the occipital and retro-auricular scalp — are comparatively protected, and that region is well vascularised. It is the same anatomical fact that makes hair transplantation possible.

Three 2.5 mm punch biopsies are taken from that protected area under local anaesthetic — a scalp treatment for hair loss that begins with the patient’s own tissue. The tissue is then mechanically disaggregated and filtered using Rigenera® technology, producing micrografts of approximately 80 microns.

What results is a suspension containing progenitor cells, signalling factors and extracellular matrix — all derived from the patient's own tissue. This is injected into the thinning regions of the scalp as a scalp treatment for hair loss directed at the follicular environment, with the aim of supporting hair regrowth from follicles still present.

Donor and recipient are the same person, within one session. Nothing foreign is introduced.

Key facts
Technology
Rigenera® autologous micrografting technology (AMT)
Autologous
The tissue comes from the patient. Donor and recipient are the same person in a single session
Donor site
The occipital and retro-auricular scalp — chosen because these follicles are comparatively protected from DHT and the area is well vascularised
Harvest
Three punch biopsies of 2.5 mm
Processing
Mechanical disaggregation and calibrated filtration, producing micrografts of approximately 80 microns
What is injected
A suspension of progenitor cells, signalling factors and extracellular matrix derived from the patient's own tissue
Regulatory status
CE-certified for androgenetic alopecia
Setting
Outpatient. No hospitalisation, no general anaesthetic, no donor strip

Two Points of Accuracy

This is not a hair transplant. A transplant relocates intact follicular units, and the moved hairs are the result. Regenera Activa moves no follicles. It introduces a cellular suspension intended to act on follicles already present in the thinning area. Different procedures, different situations — and sometimes used together.

Nor is it accurately a stem cell treatment, though it is often described that way. The suspension contains progenitor cells, which are more restricted in what they can become than stem cells. The distinction matters because the looser description promises more than the procedure delivers.

“A miniaturising follicle can respond. A follicle that has closed cannot. Everything else follows from that.”

Dr Sin YongOn why staging comes first

Where It Sits Alongside Everything Else

Any hair loss treatment Singapore patients consider has to start from one fact: androgenetic alopecia is progressive, and no single approach halts it outright. A considered plan usually draws on more than one route.

Topical and oral therapy act on follicular perfusion and on the conversion of testosterone to DHT respectively — the circulation and the hormonal driver. Laser therapy is directed at scalp perfusion and the follicular environment. Micrografting acts through a third route again.

Which combination of hair regrowth treatment applies to you follows from the assessment, the stage identified, and your own circumstances and preferences.

Response to any hair loss treatment varies with the stage of loss, the cause identified, age, medical history and adherence to the plan. Suitability is assessed in person, and no treatment is appropriate for every patient.

What Determines the Cost

Treatment is planned individually, so cost follows the plan rather than a fixed list. Four things shape it:

Factors discussed at consultation

  • The extent of the area treated. A localised vertex differs from diffuse loss across the crown.
  • The stage identified at assessment. Norwood or Ludwig staging informs what the plan needs to cover.
  • Whether one approach or several. Micrografting alone differs from a plan combining medical and laser management.
  • How the plan is staged over time. Maintenance is considered separately from the initial course.

A figure quoted before assessment would not reflect your presentation. Cost is set out clearly at consultation, before anything is agreed.

Reference

Role of Autologous Micrografting Technology through the Rigenera® System in the Treatment of Androgenetic Alopecia. Skin Appendage Disorders, Karger. karger.com

Who it suits, who should wait, who is referred on

Tends to suit

  • Male or female pattern hair loss at a stage with miniaturising follicles still present
  • Thinning at the vertex, crown or central parting
  • People who prefer an outpatient procedure using their own tissue
  • Those who accept it complements, rather than replaces, medical therapy

Better to wait

  • Pregnancy or breastfeeding
  • Active scalp infection or inflammation
  • Hair loss whose cause has not yet been established, such as thyroid or iron concerns

Referred on

  • Advanced loss with few follicles remaining → hair transplant assessment
  • Suspected non-androgenetic or scarring hair loss → medical or dermatology review
Who should not have this treatment
  • Pregnancy or breastfeeding
  • Active infection or inflammatory disease of the scalp
  • Allergy to local anaesthetic
  • Bleeding disorder or blood-thinning medication that needs review first
  • Scarring hair loss, or hair loss from a cause not yet investigated
  • A tendency to keloid or poor wound healing at the donor site

People with advanced loss and few follicles remaining, or who expect the density of a hair transplant, tend to respond poorly, and a transplant assessment suits them better.

What happens, step by step

  1. Consultation and staging on the Norwood or Ludwig scale, with other causes excluded
  2. Written plan and quote, including whether treatment alone or a combined plan is advised
  3. Treatment day: small scalp samples taken under local anaesthetic, processed and injected in the same visit
  4. Review and adjustment, alongside any medical or laser management

Risks, side effects and when to call

Mild soreness, small donor-site wounds, localised swelling and tenderness or tightness in the treated scalp are expected after the procedure. Less commonly, there can be bleeding, infection at a donor or injection site, a small visible mark, or altered sensation. Local anaesthetic can occasionally cause a reaction. Any hair loss treatment is influenced by stage, cause, age, medical history and adherence to the plan, and androgenetic alopecia is progressive, so no outcome can be promised and no single approach halts it outright.

Contact the clinic the same day if
  • Bleeding from a donor site that does not stop with gentle pressure
  • Spreading redness, warmth, pus or fever
  • Pain or swelling that is increasing rather than settling
  • A donor-site wound that is opening or not healing
  • Rash, facial swelling or breathlessness after the procedure

See what to do if something feels wrong after a treatment.

Aftercare

First 24 hours

  • Expect soreness at the donor sites and tightness in the treated scalp; keep donor sites clean and dry as advised
  • Avoid rubbing, scratching or pressure on the scalp

First week

  • Wash and style the hair gently, following the clinic's advice on when to resume normal washing
  • Avoid strenuous exercise, saunas and swimming until the donor sites have healed

Sun

  • Protect the scalp from direct sun with a hat or shade

Skincare

  • Use gentle hair and scalp products and avoid harsh treatments such as colouring or chemical straightening until advised

When to call

  • Bleeding that does not stop, or spreading redness, pus or fever
  • A donor-site wound that is opening, or pain and swelling that are increasing

Before you book

What determines the fee

The fee depends on the extent of the area treated, since a localised vertex is planned differently to diffuse loss across the crown. It also depends on the stage identified at assessment, the consumables used, and whether micrografting is used alone or combined with medical or laser management. A written quote is given at consultation after examination, and the consultation decides whether treatment is advised at all.

How quotes work at this practice: how we quote.

Myths we hear in clinic

“Regenera Activa is a hair transplant.”

A transplant relocates intact follicular units; Regenera Activa moves no follicles and introduces a suspension intended to act on follicles already present.

“Regenera Activa is a stem cell treatment.”

The suspension contains progenitor cells, which are more restricted in what they can become than stem cells.

Regenera Activa — Frequently Asked Questions

Regenera Activa is an autologous micrografting treatment for hair loss. Three small 2.5 mm punch biopsies are taken from the occipital scalp, mechanically disaggregated and filtered to produce a suspension of progenitor cells, signalling factors and extracellular matrix, which is then injected into the thinning areas. Because the tissue comes from the patient, donor and recipient are the same person within one session.

No. A hair transplant moves intact follicular units from a donor area to a recipient area, and the transplanted hairs are the result. Regenera Activa does not move follicles. It introduces a cellular suspension intended to act on follicles already present in the thinning area. The two are different procedures answering different situations, and in some cases they are used alongside one another.

Female pattern hair loss is one of the presentations Regenera Activa is used for. Female pattern loss usually presents as diffuse thinning over the crown with the frontal hairline preserved, staged on the Ludwig scale, and behaves differently from male pattern loss. Suitability is decided by assessment rather than by pattern alone.

The Norwood scale is the standard classification for male pattern hair loss, running from Type I to Type VII. It describes the progression from minimal temporal recession through to loss of the bridge between the frontal and vertex regions. Staging matters because earlier stages retain more miniaturising follicles capable of responding to treatment.

The Ludwig scale classifies female pattern hair loss in three grades. Grade I is perceptible thinning over the crown with the hairline preserved; Grade II shows pronounced widening of the central parting; Grade III shows diffuse thinning with the scalp readily visible. Unlike male pattern loss, the frontal hairline is typically maintained throughout.

They are related but not identical, and the distinction is worth making because the treatment is often described loosely as a stem cell procedure. Progenitor cells are more restricted in what they can become than stem cells are. The suspension produced by micrografting contains progenitor cells alongside signalling factors and extracellular matrix. Describing it as a stem cell transplant overstates what the procedure does.

Not necessarily. Topical therapy acts on follicular perfusion and oral therapy blocks the conversion of testosterone to DHT, addressing the hormonal driver. Micrografting acts through a third route. Because androgenetic alopecia is progressive, plans commonly combine approaches rather than relying on one, and what is appropriate is decided at consultation.

Local anaesthetic is used at both the donor and recipient sites. Most patients describe pressure rather than pain. Tolerance varies between individuals, and comfort is discussed and managed during the session.

Cost depends on the extent of the area treated, the stage of hair loss identified at assessment, and whether the plan combines micrografting with medical or laser management. Because these differ between patients, a figure quoted before assessment would not be meaningful. Pricing is set out clearly at consultation.

Suitability is assessed in person. Scarring alopecia, active scalp infection or inflammation, certain autoimmune and medical conditions, bleeding disorders, and pregnancy are among the things considered. Very pronounced hair loss with few remaining follicles is also unlikely to benefit, and saying so is part of an honest assessment.

The cost of Regenera Activa in Singapore depends on the extent of the area treated, the stage identified at assessment, the consumables used, and whether micrografting is combined with medical or laser management. Dr Sin Yong gives a written quote at consultation after staging your hair loss, because the assessment decides whether treatment is advised at all. No figure is quoted beforehand.

It is worth considering for pattern hair loss at a stage where miniaturising follicles remain, in someone who wants a procedure using their own tissue and accepts that it works alongside other therapy. It is a poor fit where follicles are already lost, where the cause is not androgenetic, or where the expectation is the density a hair transplant gives.

How long any effect from Regenera Activa lasts depends on the stage and cause of hair loss, your age, medical history, how well the plan is followed, and whether other therapy continues. Androgenetic alopecia is progressive, so no duration can be promised. Review timing, and whether repeat treatment is sensible, are decided with Dr Sin Yong at consultation.

It works only on follicles that are still present, does not halt progressive hair loss outright, and is not a hair transplant. Donor-site soreness, small wounds and tenderness are expected; bleeding, infection or anaesthetic reactions are uncommon. Response varies, repeat treatment may be considered, and it usually sits alongside medical or laser management rather than replacing it.

Question not answered here? Ask on WhatsApp, use the enquiry form, or browse 100 questions patients ask.

Where Dr Sin Yong consults: Wheelock Place, 501 Orchard Road, Singapore 238880 (unit on booking) · Orchard MRT · Mon–Fri 10am–8pm, Sat 11am–3pm · WhatsApp +65 8023 7170 · Getting here · How fees are quoted
References

1. Lolli F, Pallotti F, Rossi A, et al. Androgenetic alopecia: a review. Endocrine 2017;57(1):9-17. PubMed

2. Gupta AK, Bamimore MA, Foley KA. Efficacy of non-surgical treatments for androgenetic alopecia in men and women: a systematic review with network meta-analyses, and an assessment of evidence quality. J Dermatolog Treat 2022;33(1):62-72. PubMed

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Medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last updated 5 September 2026 · Editorial policy

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