Conditions · Treatments · Scar Revision

Rejuran S (Polynucleotide Scar Treatment)

Medically reviewed by Dr Sin Yong · Last reviewed · 9 min read · Assessed personally by Dr Sin Yong · Jump to questions

Rejuran S is the scar-specific formulation of the polynucleotide family — a thicker, more viscous preparation of DNA-fragment biostimulant, injected directly beneath depressed acne scars. Where lasers remodel by controlled injury, polynucleotides work the repair side: supporting the regeneration environment so remodelling scars rebuild with better-quality tissue. It is a supporting actor with growing evidence — and it is at its best inside a programme, not instead of one.

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Rejuran S is the scar-specific polynucleotide formulation: a thicker, more viscous preparation of purified DNA fragments injected focally beneath depressed acne scars. It differs from Rejuran Healer, which is spread through the dermis for skin quality. Rather than remodelling by controlled injury as lasers do, it supports the repair environment, and it is used within a scar programme.

Key takeaways
  • Rejuran S is a thicker polynucleotide preparation placed focally beneath depressed acne scars, used within a scar programme.
  • It differs from Rejuran Healer, which is spread through the dermis for overall skin quality.
  • Polynucleotides support the repair environment of the scar bed; they do not release tethers or fill a scar base.
  • Scar type decides the method: release, resurfacing, acid or filling. Rejuran S is usually an adjunct to those steps.
  • Dr Sin Yong assesses each scar type and sequences Rejuran S alongside subcision and fractional laser where suitable.
On this page
  1. Key Facts
  2. What is Rejuran S and how does it differ from Rejuran Healer?
  3. What does the evidence actually show?
  4. Where Rejuran S fits in the scar programme
  5. What doesn't work
  6. Which type do you have?
  7. What does not work, and why
  8. When to see a doctor
  9. Myths we hear in clinic
  10. Rejuran S, Rejuran Healer and Rejuran I: what is the difference?
  11. Which acne scars suit Rejuran S, and which need something else?
  12. Questions Patients Actually Ask

Key Facts

What it is
Purified polynucleotides (PN/PDRN) — DNA fragments with regenerative signalling activity — in a viscous scar-grade formulation
Rejuran S vs Healer
Same molecule family; S is thicker and placed focally under scars, Healer is spread dermally for skin quality
The mechanism
Supports fibroblast activity, microcirculation and a regenerative healing environment in the scar bed
The evidence
Systematic reviews of randomised trials support PN/PDRN in skin regeneration and scar-adjacent indications
Suitable scars
Depressed, tethered-soft scars — often alongside subcision and fractional energy work
The honest frame
An adjunct that improves the terrain — not a solo replacement for structural scar revision
Three small glass ampoules of clear and pale-blue solution standing on white marble
Illustrative. Injectable preparations differ in what they are and what they can do.

What is Rejuran S and how does it differ from Rejuran Healer?

Both carry the same active family — polynucleotides, purified DNA fragments whose regenerative signalling has been studied for years in wound healing [1]. The difference is formulation and job description. Rejuran Healer (the version on the Rejuran facial page) is a lighter preparation distributed through the dermis for overall skin quality. Rejuran S is the scar specialist: thicker, more cohesive, and placed focally beneath a depressed scar, where its viscosity gives mild immediate support while its biology goes to work on the scar bed's repair environment.

Close-up of uneven skin texture with raised and depressed areas
Scar type decides the method: release, resurfacing or filling.

What does the evidence actually show?

The polynucleotide literature has matured from tradition to trials: systematic reviews of randomised studies support PN/PDRN across skin regeneration, healing support and scar-adjacent indications, with a consistent safety profile [1,2]. The honest reading for acne scars specifically: PN is a legitimate biological adjunct with supportive evidence, not a structural monotherapy — a depressed scar tethered by fibrous bands still needs the tether released, and a deep ice pick still needs CROSS. Where PN earns its place is quality: treated scar beds heal from energy sessions with better-conditioned tissue, which is exactly the job a supporting biological should do.

Where Rejuran S fits in the scar programme

In Dr Sin Yong's sequencing, Rejuran S slots between and after the structural moves: after subcision releases a rolling scar, PN supports the released bed; between Tetra Pro fractional sessions, it feeds the remodelling the laser initiated; under stubborn depressed scars, it adds biological pressure where energy alone plateaus. Scar-type mapping (see the scar guide) decides where it earns its cost — and where it would be an expensive way to avoid the treatment the scar actually needs.

What doesn't work

PN as a solo fix for structural scars — biology cannot un-tether a band or fill a well. Judging it like filler — polynucleotides are biostimulants; the change is gradual tissue-quality improvement, not instant volume. Endless standalone sessions without a programme — the adjunct logic only pays inside a sequence. And brand worship in either direction — the molecule family has evidence; the plan around it is what delivers.

“Polynucleotides improve the terrain a scar heals on — but no biology un-tethers a band or fills a well, which is why Rejuran S belongs inside a programme, not instead of one.”

— Dr Sin Yong

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Which type do you have?

Acne scar types and where Rejuran S fits
Type / look-alikeHow to recognise itWhat it needsWhat does not work
Rolling scar (tethered)Broad, soft dips that stay down when the skin is stretchedSubcision to release the band; Rejuran S may support the released bedPolynucleotides alone, which cannot release a tether
Boxcar scarRound or oval dips with sharp vertical wallsFractional CO2 laser; Rejuran S may support remodelling between laser visitsJudging polynucleotides as an instant filler
Icepick scarNarrow, deep, pit-like tractsTCA CROSS directed into the tractInjection beneath the scar as a stand-alone fix
Shallow depressed scarSoft dip in the skin contour without a fibrous tetherFocal Rejuran S inside a plan, alongside energy treatmentRepeated stand-alone injections without a programme
Keloid or hypertrophic scarRaised, firm scar tissue overgrowing its boundaryA separate intralesional pathway, assessed firstDepressed-scar methods, including Rejuran S

What does not work, and why

When to see a doctor

Myths we hear in clinic

“Rejuran S works like a filler and lifts the scar straight away.”

Polynucleotides are biostimulants, so the change is gradual improvement in tissue quality rather than instant volume.

“Rejuran S alone can fix any acne scar.”

Structural scars need structural treatment, and Rejuran S supports the healing terrain around those steps.

Rejuran S, Rejuran Healer and Rejuran I: what is the difference?

The three share a molecule family, purified polynucleotide fragments, and differ in formulation and in the skin they are made for. Rejuran Healer is the standard facial preparation, spread through the dermis for skin quality. Rejuran S is the higher-viscosity preparation intended for scarred skin, where the material is placed into and around the scar rather than across a field. Rejuran I is the lower-viscosity preparation intended for the thin skin around the eyes. This page is about S, and it is the one that belongs in a scar programme. Choosing between them is a question of which skin is being treated, which is decided at examination and not by product name.

Rejuran S, Rejuran Healer and Rejuran I compared
ProductFormulationWhere it is placedDirected atWhat it does not do
Rejuran SHigher-viscosity polynucleotide preparationInto and around depressed scars, focallyThe skin-quality side of acne scarring, alongside structural scar workRelease a tethered scar or fill a scar base
Rejuran HealerStandard facial polynucleotide preparationIntradermally, spread across the faceTexture, fine lines and overall skin qualityRelease a tethered scar or add volume
Rejuran ILower-viscosity preparationThe thin skin of the periorbital areaFine lines and crepey skin around the eyesCorrect hollowing, shadow or herniated fat under the eyes

Which acne scars suit Rejuran S, and which need something else?

Rejuran S suits depressed scars where the skin has lost quality but is not held down by a fibrous band: a soft, shallow dip that does not need releasing. Even there it is used inside a plan, alongside energy treatment, not as a stand-alone fix. Its place in other scar types is supportive. After subcision releases a rolling scar, it may support the released bed. Between fractional CO2 visits with the Tetra Pro SCAR3 programme, it may support the remodelling the laser began. Boxcar scars with sharp walls still need resurfacing as the structural step. Which of these applies is decided by mapping each scar on the cheek, not by the product.

Some scars need something else first. A narrow, deep ice pick tract needs TCA CROSS directed into the tract, because injecting beneath it does not change its depth. A raised, firm or growing scar may be a keloid or hypertrophic scar, which follows a separate intralesional pathway after assessment, and depressed-scar methods including Rejuran S are not used on it. Active acne is controlled before any scar work, and because polynucleotides are usually derived from salmon DNA, a fish allergy is raised first. Mixed scars on one cheek are the rule rather than the exception, so a scar-by-scar assessment comes before a plan.

Questions Patients Actually Ask

Is Rejuran S the same as Rejuran Healer?+

Same polynucleotide family, different formulation and job: Healer spreads through the dermis for skin quality; S is thicker and placed focally beneath scars.

How many sessions does Rejuran S take?+

Courses of a few sessions weeks apart are typical, planned around the energy treatments it supports. The response is cumulative, like all biostimulants.

Does it hurt?+

Injections under scar tissue sting briefly; numbing cream and technique keep it very tolerable. Expect small raised blebs that settle within a day or so.

Is it safe?+

The PN/PDRN literature reports a consistent safety profile across trials — it is a well-tolerated biological. Screening at assessment covers the exceptions.

Will Rejuran S fix my scars alone?+

Depressed structural scars need structural treatment; PN improves the healing terrain around those moves. Anyone selling it as a standalone scar cure is overselling the molecule.

Rejuran S or laser first?+

Usually mapped together — energy initiates remodelling, PN supports it. Sequence depends on your scar census, set at assessment.

What causes acne scars?+
Acne scars form when inflammation damages the collagen in and around a follicle and the skin repairs itself unevenly. Loss of tissue gives rolling, boxcar or icepick scars, while overgrowth gives raised scars. A single cheek often carries several types, which is why each scar is mapped by structure before any plan is made.
Can acne scars be fully removed?+
Scars are reduced and remodelled, not erased. Rejuran S supports the repair environment of a depressed scar but does not release a tether or rebuild a scar base, so it is used alongside structural methods. The realistic scope for your scars is explained at assessment, before anything is booked.
Which treatment suits depressed acne scars?+
It depends on scar type. Tethered rolling scars are released by subcision, icepick tracts are treated with TCA CROSS, and boxcar scarring is rebuilt with fractional CO2 laser. Rejuran S may be added as a biological adjunct. Scar type, skin type, pigment history and timing decide the sequence, which is set after a scar-by-scar assessment.
How much does Rejuran S treatment cost in Singapore?+
The cost follows the plan rather than a fixed list. It depends on the number and area of scars treated, the amount of product used, whether it sits alongside subcision, laser or TCA CROSS, and how the plan is staged. A written quote is given at consultation after assessment, and the consultation decides whether Rejuran S is advised at all.

References

  1. Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials — PubMed.
  2. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review — Journal of Cosmetic Dermatology.

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Medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last updated 7 October 2026 · Editorial policy

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